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What's the main difference between traditional NSAIDs and COX-2 inhibitors?
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You have 2 types of COX enzymes in your body: COX-1 and COX-2. Researchers believe that one of the jobs of COX-1 enzymes is to help protect your stomach lining. The COX-2 enzyme doesn't play a role in protecting your stomach.
Traditional NSAIDs stop both COX-1 and COX- 2 enzymes from doing their jobs. When COX-1 enzymes are blocked, pain and inflammation is reduced, but the protective lining of your stomach is also reduced. This can cause problems such as upset stomach, ulcers and bleeding in your stomach and intestines.
COX-2 inhibitors only stop COX-2 enzymes from working. Since the COX-2 enzyme doesn't help to protect your stomach, COX-2 inhibitors may be less likely to irritate your stomach or intestines.
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