Other drugs that help with pain are called nonsteroidal anti-inflammatory drugs, or NSAIDs. Examples include aspirin, ibuprofen (two brand names: Motrin, Advil) and naproxen (two brand names: Aleve [over the counter], Naprosyn [prescription]). These medicines can be taken just when you need them, or they can be taken every day. When these medicines are taken regularly they build up in the blood to levels that fight the pain of inflammation (swelling) and also give general pain relief. Many of these medicines are available in low-dose forms without a prescription.
NSAIDs reduce inflammation and relieve fever and pain by blocking enzymes and proteins made by the body. NSAIDs such as ibuprofen and naproxen block a protein (called prostaglandin) that makes heavy menstrual bleeding worse. Aspirin does not block this protein.
Nonsteroidal anti-inflammatory drugs (NSAIDs) you can buy without a prescription (not a complete list)
| Generic Name |
Brand Name |
| ibuprofen |
Advil, Motrin |
| naproxen sodium |
Aleve |
| aspirin |
Bayer, Bufferin |
Because aspirin can increase the risk of bleeding, it is not recommended for new injuries. Take other medicines such as ibuprofen or naproxen for the first 2 or 3 days after an injury.
Prescription NSAIDs (not a complete list)
| Generic Name |
Brand Name |
| celecoxib |
Celebrex |
| ibuprofen |
Motrin |
| ketoprofen |
|
| naproxen sodium |
Anaprox |
| piroxicam |
Feldene |
| sulindac |
Clinoril |
If your doctor prescribed NSAIDs, take them exactly as prescribed. Call your doctor if you have any problems with your medicine. Always read and follow all instructions on the label.
The most common side effects of NSAIDs are stomach upset, heartburn, ulcers, and skin rashes. Taking NSAIDs with food may help prevent some of these problems. Your chances of having these side effects are greater if you take large doses of NSAIDs or take them for a long time.
Less common side effects include confusion; swelling of the face, feet, or lower legs; or a sudden decrease in the amount of urine. These side effects are more likely to occur in older adults and people with other serious health problems.
Aspirin, unlike other NSAIDs, has been shown to reduce the risk of heart attack and stroke. If you use other NSAIDs regularly, aspirin may not work as well to prevent a heart attack and stroke. Do not give aspirin to anyone younger than 20 unless your doctor tells you to. It has been linked to Reye syndrome, a rare but serious illness.
If you are pregnant, trying to become pregnant, or breast-feeding, talk to your doctor before you use NSAIDs. Do not use NSAIDs during pregnancy unless your doctor tells you to. They can cause problems with your baby or with delivery.
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
