What can you do about being dizzy and nauseous on Tramadol?

June 15th, 2011 by FioricetSoma Leave a reply »
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Josh Winters asked:


My girlfriend takes tramadol for pain (doctor prescribed, not addicted) but every time she does she gets really dizzy and has a hard time walking and moving. She also sleeps for a couple of hours if she takes it during the day but has a hard time staying asleep at night cause she says she feels lightheaded and dizzy. She also always vomits even when she eats a substantial amount of food before she takes it. Thanks.

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3 comments

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    How much is she taking? How much does she weigh? What is her height? How old is she? What other drugs is she on? Is she on any anti-depressants like Paxil, Prozac or Zoloft, or MAOI-antidepressants like selegiline (l-deprenyl, many trade names)? Does she use any recreational drugs?

    Tramadol isn’t an opioid in the truest sense- tramadol itself has only negligible affinity for the mu-opioid receptor; it primarily relieves pain through modulation of monoamines (serotonin, norepinephrine, and dopamine). Tramadol’s main metabolite, however, O-desmethyltramadol (as codeine is to morphine, tramadol is to O-desmethyltramadol) is a very strong opioid. If I remember correctly, it is either >200x more potent than tramadol as an opioid, or >200 times more potent than morphine. Either seems possible, even reasonable, but I’m having trouble finding the number.

    Anyway, the nausea and vomiting are common side effects of opiates.

    If the drug is not the extended release variety, she can break it in half without problems. This may relieve the problem. Discontinuing it is another option.

    She may be able to just persist and eventually develop a tolerance to this effect.

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